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Sodium-Iodide Symporter Antibody
Sodium Iodide Symporter Antibody, Clone 14F
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q92911 |
| Other Accession | NP_000444.1 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human Sodium-Iodide Symporter Monoclonal IgG1 |
| Target/Specificity | Detects ~97kDa, non-glycosylated version at 68kDa. Other minor bands associated with hNIS at 160kDa, and degradation products at ~30 kDa, and ~15kDa. |
| Other Names | NIS Antibody, SLC5A5 Antibody, solute carrier family 5 Antibody, Na (+)I(-) cotransporter Antibody |
| Clone Names | 14F |
| Immunogen | Mannose binding protein hNIS fusion (AA468-643) |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 1 µg/ml of SMC-390 was sufficient for detection of hNIS in 20 µg of transfected COS-7 cell membrane lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
The sodium iodide symporter (NIS) is an ion pump that actively transports iodide across the basolateral membrane into thyroid epithelial cells (1, 2). This is important step in the process of iodide organificaton and the formation of triiodothyronine and thyroxine (3).
References
1. Dai G., Levy O., Carrasco N. (1996) Nature. 379(6564): 458-460.
2. Snabik P.A., et al. (1997) Endocrin. 138(8): 3555-3558.
3. Dohan O., et al. (2007) Proc Natl Acad Sci USA. 104(51): 20250-20255.
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