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Neuroligin 1 Antibody
Neuroligin 1 Antibody, Clone S97A-31
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC/IF |
|---|---|
| Primary Accession | Q62765 |
| Other Accession | NP_446320.1. |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat Neuroligin 1 Monoclonal IgG1 |
| Target/Specificity | Detects ~120kDa. Does not cross-react with other Neuroligins. |
| Other Names | NLG 1 Antibody, KIAA1070 Antibody, MGC45115 Antibody, Neuroligin-1 Antibody, NL1 Antibody, NLG1 Antibody, Nlgn1 Antibody |
| Clone Names | S97A-31 |
| Immunogen | Fusion protein amino acids 718-843 (cytoplasmic C-terminus) of rat Neuroligin-1. Mouse: 99% identity (125/126 amino acids identical). Human: 99% identity (125/126 amino acids identical) >40% identity with Neuroligin-2 and -3. |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH 7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | 2 µg/ml of SMC-463 was sufficient for detection of Neuroligin-1 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane | Cell Junction | Synapse | Postsynaptic Cell Membrane | Postsynaptic Density |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.
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