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Kv3.2 Antibody
Kv3.2 Antibody, Clone S410-17
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC/IF |
|---|---|
| Primary Accession | P22462 |
| Other Accession | NP_631962.1 |
| Host | Mouse |
| Isotype | IgG1 |
| Reactivity | Human, Mouse, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Rat Kv3.2 Monoclonal IgG1 |
| Target/Specificity | Detects ~80-100kDa. Varies due to post-translational modifications. |
| Other Names | Potassium voltage-gated channel subfamily C member 2 Antibody, Kcnc2 Antibody, KSHIIIA Antibody |
| Clone Names | S410-17 |
| Immunogen | Fusion protein amino acids 474-613 (Cytoplasmic C-terminus) of rat Kv3.2a |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:100 dilution of SMC-492 was sufficient for detection of Kv3.2 in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
Kv3.2, a member of the KCNC2 gene family, belongs to a group of potassium channels that contribute to the maintenance of cell volume, membrane potential, neuronal excitability and the secretion of transmitters, salt and hormones. Kv3.2 are predominantly expressed in neurons that fire at high frequencies, and in the fast spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus (1-3). They specifically functioning as a delayed rectifier activated by large membrane depolarizations (2, 4).
References
1. Kolodin Y.O. (2008) http://ykolodin.50webs.com/
2. Rudy B., McBain C.J. (2001) Trends Neurosci. 24(9): 517-526.
3. Gutman G.A., et al. (2005) Pharmacol Rev. 57(4): 472-508.
4. Rudy B, et al. (1999) Ann. NY Acad. Sci. 868: 304-343.
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