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GABA A Receptor Epsilon Antibody
GABA A Receptor Epsilon Antibody, Clone S413-67
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, ICC/IF |
|---|---|
| Primary Accession | P78334 |
| Other Accession | NP_004952.2 |
| Host | Mouse |
| Isotype | IgG2A |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Description | Mouse Anti-Human GABA A Receptor Epsilon Monoclonal IgG2A |
| Target/Specificity | Detects ~60kDa. |
| Other Names | Gamma-aminobutyric acid receptor subunit epsilon Antibody, GABRE Antibody |
| Clone Names | S413-67 |
| Immunogen | Fusion protein amino acids 27-253 (Extracellular N-terminus) of human GABA A Receptor Epsilon |
| Purification | Protein G Purified |
| Storage | -20ºC |
| Storage Buffer | PBS pH7.4, 50% glycerol, 0.1% sodium azide |
| Shipping Temperature | Blue Ice or 4ºC |
| Certificate of Analysis | A 1:100 dilution of SMC-493 was sufficient for detection of GABA-A R, Epsilon in 20 µg of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. |
| Cellular Localization | Cell Junction | Synapse | Postsynaptic Cell Membrane | Cell Membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
The GABA A Receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2). Brainstem expression of GABA-A Receptor, Epsilon, is upregulated during pregnancy (3).
References
1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136.
2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.
3. Hengen K.B., et al. (2012) PLoS One. 7(1): e30608.
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