ACD Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant ACD.
|Application ||WB, IHC, IF, IP, E|
|Calculated MW||57733 Da|
|Other Names||Adrenocortical dysplasia protein homolog, POT1 and TIN2-interacting protein, ACD, PIP1, PTOP, TINT1, TPP1|
|Target/Specificity||ACD (AAH16904, 1 a.a. ~ 544 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ACD Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
1.TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP.Mol Cell Biol. 2010 Apr 19. [Epub ahead of print]
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