ADH4 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant ADH4.
|Application ||WB, IHC, E|
|Calculated MW||40222 Da|
|Other Names||Alcohol dehydrogenase 4, Alcohol dehydrogenase class II pi chain, ADH4|
|Target/Specificity||ADH4 (NP_000661, 52 a.a. ~ 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ADH4 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. Preuss UW, et al. Addict Biol, 2010 Jul 9. PMID 20626721.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.Identification of a FOXA-dependent enhancer of human alcohol dehydrogenase 4 (ADH4). Pochareddy S, et al. Gene, 2010 Jul 15. PMID 20363298.Cluster headache is associated with the alcohol dehydrogenase 4 (ADH4) gene. Rainero I, et al. Headache, 2010 Jan. PMID 19925625.
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