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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AES Antibody (monoclonal) (M02)   

AES Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant AES.

  • E - AES Antibody (monoclonal) (M02) AT1063a
    Detection limit for recombinant GST tagged AES is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08117
Other Accession NM_001130
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 10
Calculated MW 21970 Da
Additional Information
Gene ID 166
Other Names Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5
Target/Specificity AES (NP_001121, 2 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsAES Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.


Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription. Zhang Y, et al. Biochem J, 2010 Apr 14. PMID 20163360.Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. Arce L, et al. BMC Cancer, 2009 May 21. PMID 19460168.Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Zhang X, et al. J Neurosci Res, 2008 Aug 15. PMID 18438919.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.

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$ 315.00
Cat# AT1063a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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