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AES Antibody (monoclonal) (M02)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1063a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AES Antibody (monoclonal) (M02) - Product info | |
| Application | WB
|
| Primary Accession | Q08117 |
| Other Accession | NP_001121 |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 10 |
| Calculated MW | 21970 Da |
AES Antibody (monoclonal) (M02) - Additional info | |
| Gene ID 166 | |
| Other Names AES1, AES2, ESP1, GRG, GRG5, TLE5amino-terminal enhancer of split | |
| Target/Specificity AES (NP_001121, 2 a.a. ~ 111 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AES Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AES Antibody (monoclonal) (M02) - Related products
AES Antibody (monoclonal) (M02) - Application data
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AES monoclonal antibody (M02), clone 1E1 Western Blot analysis of AES expression in Hela NE ( Cat # L013V3 ).
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Detection limit for recombinant GST tagged AES is approximately 1ng/ml as a capture antibody.
AES Antibody (monoclonal) (M02) - Research Areas
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BACKGROUND
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription. Zhang Y, et al. Biochem J, 2010 Apr 14. PMID 20163360.Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. Arce L, et al. BMC Cancer, 2009 May 21. PMID 19460168.Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Zhang X, et al. J Neurosci Res, 2008 Aug 15. PMID 18438919.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.
