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AFP Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1066a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
AFP Antibody (monoclonal) (M01) - Product info | |
| Application | IF, WB
|
| Primary Accession | P02771 |
| Reactivity | Human |
| Isotype | IgG Mix Kappa |
| Clone Names | 1G7 |
| Calculated MW | 68678 Da |
AFP Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 174 | |
| Other Names FETA, HPAFPalpha-fetoprotein | |
| Target/Specificity AFP (AAH27881, 500 a.a. ~ 610 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AFP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AFP Antibody (monoclonal) (M01) - Related products
AM1835a: AFP Antibody (N-term)
AM1835b: AFP Antibody (Ascites)
AP1430a: AFP Antibody (N-term)
AP1430c: AFP Antibody (Center)
BP1430a: AFP Antibody (N-term) Blocking Peptide
AFP Antibody (monoclonal) (M01) - Application data
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Immunofluorescence of monoclonal antibody to AFP (AT1066a) on HepG2 cell . [antibody concentration 30 ug/ml]
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Western Blot analysis of AFP expression in transfected 293T cell line by AFP monoclonal antibody (M01), clone 1G7.
Lane 1: AFP transfected lysate(69 KDa).
Lane 2: Non-transfected lysate.
AFP Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
REFERENCES
Clinicopathologic features and prognostic factors in alpha-fetoprotein-producing gastric cancers: analysis of 104 cases. Liu X, et al. J Surg Oncol, 2010 Sep 1. PMID 20740583.Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma. McHugh PP, et al. HPB (Oxford), 2010 Feb. PMID 20495646.Differential diagnosis of liver diseases using serum biomarkers. Cujic D, et al. J BUON, 2010 Jan-Mar. PMID 20414942.High-efficient expression, refolding and purification of functional recombinant C-terminal fragment of human alpha-fetoprotein. Sharapova OA, et al. Protein Expr Purif, 2010 Sep. PMID 20363333.Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma. Ishii T, et al. Cancer Lett, 2010 Aug 1. PMID 20149523.
