ALAS2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant ALAS2.
|Application ||WB, E|
|Calculated MW||64633 Da|
|Other Names||5-aminolevulinate synthase, erythroid-specific, mitochondrial, ALAS-E, 5-aminolevulinic acid synthase 2, Delta-ALA synthase 2, Delta-aminolevulinate synthase 2, ALAS2, ALASE, ASB|
|Target/Specificity||ALAS2 (NP_000023, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ALAS2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.
1.Emodin can induce K562 cells to erythroid differentiation and improve the expression of globin genes.Ma YN, Chen MT, Wu ZK, Zhao HL, Yu HC, Yu J, Zhang JWMol Cell Biochem. 2013 Jun 7.2.Hypoxic Induction of Human Erythroid-Specific Delta-Aminolevulinate Synthase Mediated by Hypoxia-Inducible Factor 1.Zhang FL, Shen GM, Liu XL, Wang F, Zhao HL, Yu J, Zhang JW.Biochemistry. 2011 Jan 20. [Epub ahead of print]
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