AP2S1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant AP2S1.
|Application ||WB, E|
|Calculated MW||17018 Da|
|Other Names||AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Adaptor-related protein complex 2 subunit sigma, Clathrin assembly protein 2 sigma small chain, Clathrin coat assembly protein AP17, Clathrin coat-associated protein AP17, HA2 17 kDa subunit, Plasma membrane adaptor AP-2 17 kDa protein, Sigma2-adaptin, AP2S1, AP17, CLAPS2|
|Target/Specificity||AP2S1 (AAH06337, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||AP2S1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.
Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein. Byland R, et al. Mol Biol Cell, 2007 Feb. PMID 17108326.Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2. Batonick M, et al. Virology, 2005 Nov 25. PMID 16139856.Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. Stove V, et al. J Virol, 2005 Sep. PMID 16103193.PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Lu W, et al. Neuron, 2005 Aug 4. PMID 16055064.
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