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APC Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant APC.

  • WB - APC Antibody (monoclonal) (M01) AT1158a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.85 KDa) .
  • IF - APC Antibody (monoclonal) (M01) AT1158a
    Immunofluorescence of monoclonal antibody to APC on HeLa cell . [antibody concentration 10 ug/ml]
  • E - APC Antibody (monoclonal) (M01) AT1158a
    Detection limit for recombinant GST tagged APC is approximately 30ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25054
Other Accession NM_000038
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 3E3
Calculated MW 311646 Da
Additional Information
Gene ID 324
Other Names Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 25, APC, DP25
Target/Specificity APC (NP_000029, 2744 a.a. ~ 2843 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsAPC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations ( 0 )


This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.


KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC. Jaulin F, et al. J Cell Biol, 2010 Aug 9. PMID 20696710.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. Lee DY, et al. Menopause, 2010 Sep-Oct. PMID 20613673.Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study. Wish TA, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20570909.Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Albuquerque C, et al. Genes Chromosomes Cancer, 2010 Aug. PMID 20544848.

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$ 315.00
Cat# AT1158a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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