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BIRC5 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant BIRC5.

  • WB - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Western Blot analysis of BIRC5 expression in transfected 293T cell line by BIRC5 monoclonal antibody (M01), clone 5B10.

    Lane 1: BIRC5 transfected lysate(16.4 KDa).
    Lane 2: Non-transfected lysate.
  • IF - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Immunofluorescence of monoclonal antibody to BIRC5 on HeLa cell . [antibody concentration 10 ug/ml]
  • IP - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Immunoprecipitation of BIRC5 transfected lysate using anti-BIRC5 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with BIRC5 MaxPab rabbit polyclonal antibody.
  • E - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Detection limit for recombinant GST tagged BIRC5 is approximately 0.03ng/ml as a capture antibody.
  • WB - BIRC5 Antibody (monoclonal) (M01) AT1299a
    Western blot analysis of BIRC5 over-expressed 293 cell line, cotransfected with BIRC5 Validated Chimera RNAi ( (Cat # AT1299a )
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15392
Other Accession NM_001168
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 5B10
Calculated MW 16389 Da
Additional Information
Gene ID 332
Other Names Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, API4, IAP4
Target/Specificity BIRC5 (NP_001159, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsBIRC5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined.


1.Survivin expression induced by endothelin-1 promotes myofibroblast resistance to apoptosis.Horowitz JC, Ajayi IO, Kulasekaran P, Rogers DS, White JB, Townsend SK, White ES, Nho RS, Higgins PD, Huang SK, Sisson TH.Int J Biochem Cell Biol. 2011 Oct 25.2.The Closely Related RNA helicases, UAP56 and URH49, Preferentially Form Distinct mRNA Export Machineries and Coordinately Regulate Mitotic Progression.Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E, Masuda S.Mol Biol Cell. 2010 Aug 15;21(16):2953-65. Epub 2010 Jun 23.

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$ 315.00
Cat# AT1299a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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