BUB1B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant BUB1B.
|Application ||WB, IHC, IF|
|Calculated MW||119545 Da|
|Other Names||Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, MAD3/BUB1-related protein kinase, hBUBR1, Mitotic checkpoint kinase MAD3L, Protein SSK1, BUB1B, BUBR1, MAD3L, SSK1|
|Target/Specificity||BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||BUB1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Suijkerbuijk SJ, et al. Cancer Res, 2010 Jun 15. PMID 20516114.Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours. Gladhaug IP, et al. Histopathology, 2010 Feb. PMID 20459534.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus. Lira RC, et al. Oncol Rep, 2010 Apr. PMID 20204288.LSD1 is required for chromosome segregation during mitosis. Lv S, et al. Eur J Cell Biol, 2010 Jul. PMID 20189264.
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