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BUB1B Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1320a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
BUB1B Antibody (monoclonal) (M01) - Product info | |
| Application | IF
|
| Primary Accession | O60566 |
| Reactivity | Human |
| Isotype | IgG Mix Kappa |
| Clone Names | 2G9 |
| Calculated MW | 119545 Da |
BUB1B Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 701 | |
| Other Names BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | |
| Target/Specificity BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BUB1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BUB1B Antibody (monoclonal) (M01) - Related products
AP8059a: BUBR1 (BUB1B) Antibody (N-term)
AP8059b: BUB1B Antibody (Center)
AP8059d: BUB1B Antibody (N-term)
RI10657: BUB1B predesign siRNA
BP8059a: BUB1B Antibody (N-term) Blocking Peptide
BP8059b: BUB1B Antibody (Center) Blocking Peptide
BUB1B Antibody (monoclonal) (M01) - Application data
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Immunofluorescence of monoclonal antibody to BUB1B (AT1320a) on HeLa cell . [antibody concentration 10 ug/ml]
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Immunoperoxidase of monoclonal antibody to BUB1B ( Cat # AT1320a ) on formalin-fixed paraffin-embedded human spleen. [antibody concentration 1 ug/ml]
BUB1B Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
REFERENCES
Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy. Suijkerbuijk SJ, et al. Cancer Res, 2010 Jun 15. PMID 20516114.Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours. Gladhaug IP, et al. Histopathology, 2010 Feb. PMID 20459534.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus. Lira RC, et al. Oncol Rep, 2010 Apr. PMID 20204288.LSD1 is required for chromosome segregation during mitosis. Lv S, et al. Eur J Cell Biol, 2010 Jul. PMID 20189264.
