|Application ||WB, E|
|Calculated MW||32973 Da|
|Other Names||Carbonic anhydrase-related protein, CARP, Carbonic anhydrase VIII, CA-VIII, CA8, CALS|
|Target/Specificity||CA8 (NP_004047, 40 a.a. ~ 139 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CA8 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.
CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait. T?rkmen S, et al. PLoS Genet, 2009 May. PMID 19461874.Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing. Picaud SS, et al. Proteins, 2009 Aug 1. PMID 19360879.Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis. Mori S, et al. J Bone Miner Metab, 2009. PMID 19172221.Carbonic anhydrase-related protein VIII promotes colon cancer cell growth. Nishikata M, et al. Mol Carcinog, 2007 Mar. PMID 17219437.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
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