CACNA1S Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CACNA1S.
|Calculated MW||212350 Da|
|Other Names||Voltage-dependent L-type calcium channel subunit alpha-1S, Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle, Voltage-gated calcium channel subunit alpha Cav11, CACNA1S, CACH1, CACN1, CACNL1A3|
|Target/Specificity||CACNA1S (NP_000060, 1743 a.a. ~ 1838 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CACNA1S Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility.
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The role of CACNA1S in predisposition to malignant hyperthermia. Carpenter D, et al. BMC Med Genet, 2009 Oct 13. PMID 19825159.Novel CACNA1S mutation causes autosomal dominant hypokalemic periodic paralysis in a South American family. Ke T, et al. J Hum Genet, 2009 Nov. PMID 19779499.Increasing the number of diagnostic mutations in malignant hyperthermia. Levano S, et al. Hum Mutat, 2009 Apr. PMID 19191329.
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