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CACYBP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CACYBP.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HB71 |
| Other Accession | BC005975 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2E4 |
| Calculated MW | 26210 Da |
| Gene ID | 27101 |
|---|---|
| Other Names | Calcyclin-binding protein, CacyBP, hCacyBP, S100A6-binding protein, Siah-interacting protein, CACYBP, S100A6BP, SIP |
| Target/Specificity | CACYBP (AAH05975, 1 a.a. ~ 228 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CACYBP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Expression and clinical significance of CacyBP/SIP in pancreatic cancer. Chen X, et al. Pancreatology, 2008. PMID 18765951.Expression of calcyclin-binding protein/Siah-1 interacting protein in normal and malignant human tissues: an immunohistochemical survey. Zhai H, et al. J Histochem Cytochem, 2008 Aug. PMID 18443365.Calcyclin-binding protein inhibits proliferation, tumorigenicity, and invasion of gastric cancer. Ning X, et al. Mol Cancer Res, 2007 Dec. PMID 18171983.Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma. Sun S, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17400182.
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