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CALCA Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant CALCA.

     
  • WB - CALCA Antibody (monoclonal) (M01) AT1371a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.64 KDa) .
    detail
  • WB - CALCA Antibody (monoclonal) (M01) AT1371a
    Western Blot analysis of CALCA expression in transfected 293T cell line by CALCA monoclonal antibody (M01), clone 4B10.

    Lane 1: CALCA transfected lysate(15.5 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - CALCA Antibody (monoclonal) (M01) AT1371a
    Detection limit for recombinant GST tagged CALCA is approximately 1ng/ml as a capture antibody.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P06881
Other Accession NM_001741
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4B10
Calculated MW 13899 Da
Additional Information
Gene ID 796
Other Names Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I, CALCA, CALC1
Target/Specificity CALCA (NP_001732, 52 a.a. ~ 141 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCALCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

References

High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Giroux S, et al. Bone, 2010 Jul 30. PMID 20654748.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide. Zhou Z, et al. J Hypertens, 2010 May. PMID 20375903.Procalcitonin: a novel cardiac marker with prognostic value in acute coronary syndrome. Atao?lu HE, et al. J Int Med Res, 2010 Jan-Feb. PMID 20233513.Procalcitonin as a prognostic marker in patients with acute myocardial infarction. Kelly D, et al. Biomarkers, 2010 Jun. PMID 20214413.

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$ 350.00
Cat# AT1371a
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Availability: 7-10 days
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