CAPG Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant CAPG.
|Application ||WB, IF|
|Calculated MW||38499 Da|
|Other Names||Macrophage-capping protein, Actin regulatory protein CAP-G, CAPG, AFCP, MCP|
|Target/Specificity||CAPG (NP_001738, 249 a.a. ~ 348 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CAPG Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.
Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. Burillo E, et al. Atherosclerosis, 2009 Nov. PMID 19439302.Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues. Li MX, et al. Med Oncol, 2010 Mar. PMID 19242827.Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. Zhang R, et al. Am J Respir Cell Mol Biol, 2009 Oct. PMID 19188659.The actin-capping protein CapG localizes to microtubule-dependent organelles during the cell cycle. Hubert T, et al. Biochem Biophys Res Commun, 2009 Feb 27. PMID 19166812.Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. Chen M, et al. J Biol Chem, 2009 Jan 16. PMID 19011242.
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