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CASQ2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CASQ2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14958 |
| Other Accession | BC022288 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b kappa |
| Clone Names | 1B6 |
| Calculated MW | 46436 Da |
| Gene ID | 845 |
|---|---|
| Other Names | Calsequestrin-2, Calsequestrin, cardiac muscle isoform, CASQ2 |
| Target/Specificity | CASQ2 (AAH22288, 20 a.a. ~ 399 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CASQ2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
References
1.A novel mouse model of X-linked cardiac hypertrophy.Leatherbury L, Yu Q, Chatterjee B, Walker DL, Yu Z, Tian X, Lo CW.Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2701-11. Epub 2008 Apr 18.
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