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>   home   >   Products   >   Primary Antibodies   >   CBX2 Antibody (monoclonal) (M04)   

CBX2 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant CBX2.

     
  • WB - CBX2 Antibody (monoclonal) (M04) AT1409a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • E - CBX2 Antibody (monoclonal) (M04) AT1409a
    Detection limit for recombinant GST tagged CBX2 is approximately 3ng/ml as a capture antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14781
Other Accession NM_032647
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3E3
Calculated MW 56081 Da
Additional Information
Gene ID 84733
Other Names Chromobox protein homolog 2, CBX2
Target/Specificity CBX2 (NP_116036, 66 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCBX2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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Background

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

References

Ovaries and female phenotype in a girl with 46,XY karyotype and mutations in the CBX2 gene. Biason-Lauber A, et al. Am J Hum Genet, 2009 May. PMID 19361780.Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. Agrawal N, et al. PLoS One, 2008. PMID 19107218.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197.

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$ 315.00
Cat# AT1409a
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