CCNG1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CCNG1.
|Calculated MW||34074 Da|
|Other Names||Cyclin-G1, Cyclin-G, CCNG1, CCNG, CYCG1|
|Target/Specificity||CCNG1 (AAH00196, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CCNG1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. Cunningham JM, et al. Br J Cancer, 2009 Oct 20. PMID 19738611.MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Fornari F, et al. Cancer Res, 2009 Jul 15. PMID 19584283.Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A. Li H, et al. Mol Cell Biol, 2009 Feb. PMID 18981217.A role for the cyclin box in the ubiquitin-mediated degradation of cyclin G1. Piscopo DM, et al. Cancer Res, 2008 Jul 15. PMID 18632610.Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1. Seo HR, et al. J Biol Chem, 2008 Jun 6. PMID 18408012.
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