CCNK Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CCNK.
|Application ||WB, E|
|Calculated MW||64240 Da|
|Other Names||Cyclin-K, CCNK, CPR4|
|Target/Specificity||CCNK (AAH15935, 1 a.a. ~ 354 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CCNK Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
1.The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.Dowejko A, Bauer R, Bauer K, Muller-Richter UD, Reichert TE.Exp Cell Res. 2011 Nov 10.
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