CD99 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CD99.
|Application ||WB, E|
|Calculated MW||18848 Da|
|Other Names||CD99 antigen, E2 antigen, Protein MIC2, T-cell surface glycoprotein E2, CD99, CD99, MIC2, MIC2X, MIC2Y|
|Target/Specificity||CD99 (AAH03147, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CD99 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene.
Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression. Duncan LM, et al. J Immunol, 2010 Jun 15. PMID 20483773.Death induction by CD99 ligation in TEL/AML1-positive acute lymphoblastic leukemia and normal B cell precursors. Husak Z, et al. J Leukoc Biol, 2010 Aug. PMID 20453109.CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis. Rocchi A, et al. J Clin Invest, 2010 Mar 1. PMID 20197622.Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. Yoshino N, et al. Ann Thorac Cardiovasc Surg, 2009 Oct. PMID 19901887.Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. Burkhardt J, et al. J Rheumatol, 2009 Oct. PMID 19723899.
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