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CDH17 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant CDH17.

     
  • WB - CDH17 Antibody (monoclonal) (M01) AT1472a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.62 KDa) .
    detail
  • WB - CDH17 Antibody (monoclonal) (M01) AT1472a
    CDH17 monoclonal antibody (M01), clone 1H3. Western Blot analysis of CDH17 expression in human intestinal wall.
    detail
  • IHC - CDH17 Antibody (monoclonal) (M01) AT1472a
    Immunoperoxidase of monoclonal antibody to CDH17 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
    detail
  • E - CDH17 Antibody (monoclonal) (M01) AT1472a
    Detection limit for recombinant GST tagged CDH17 is approximately 0.03ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, E
Primary Accession Q12864
Other Accession NM_004063
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1H3
Calculated MW 92219 Da
Additional Information
Gene ID 1015
Other Names Cadherin-17, Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin, CDH17
Target/Specificity CDH17 (NP_004054, 24 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCDH17 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants.

References

1.Comparison of cadherin-17 expression between primary colorectal adenocarcinomas and their corresponding metastases: the possibility of a diagnostic marker for detecting the primary site of metastatic tumour.Park JH, Seol JA, Choi HJ, Roh YH, Choi PJ, Lee KE, Roh MS.Histopathology. 2011 Jan;58(2):315-8. doi: 10.1111/j.1365-2559.2011.03746.x.2.Cadherin-17 is a useful diagnostic marker for adenocarcinomas of the digestive system.Su MC, Yuan RH, Lin CY, Jeng YM.Mod Pathol. 2008 Nov;21(11):1379-86. Epub 2008 Jun 13.

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$ 350.00
Cat# AT1472a
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Availability: 7-10 days
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