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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDK4 Antibody (monoclonal) (M09)   

CDK4 Antibody (monoclonal) (M09)

Mouse monoclonal antibody raised against a partial recombinant CDK4.

  • WB - CDK4 Antibody (monoclonal) (M09) AT1476a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (35.97 KDa) .
  • WB - CDK4 Antibody (monoclonal) (M09) AT1476a
    CDK4 monoclonal antibody (M09), clone 8A10 Western Blot analysis of CDK4 expression in HeLa ( (Cat # AT1476a )
  • WB - CDK4 Antibody (monoclonal) (M09) AT1476a
    CDK4 monoclonal antibody (M09), clone 8A10. Western Blot analysis of CDK4 expression in Raw 264.7 ( (Cat # AT1476a )
  • WB - CDK4 Antibody (monoclonal) (M09) AT1476a
    CDK4 monoclonal antibody (M09), clone 8A10. Western Blot analysis of CDK4 expression in NIH/3T3 ( (Cat # AT1476a )
  • IF - CDK4 Antibody (monoclonal) (M09) AT1476a
    Immunofluorescence of monoclonal antibody to CDK4 on HeLa cell. [antibody concentration 10 ug/ml]
  • E - CDK4 Antibody (monoclonal) (M09) AT1476a
    Detection limit for recombinant GST tagged CDK4 is approximately 3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11802
Other Accession BC003644
Reactivity Human, Mouse
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 8A10
Calculated MW 33730 Da
Additional Information
Gene ID 1019
Other Names Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Target/Specificity CDK4 (AAH03644, 211 a.a. ~ 303 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCDK4 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.


Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Zeng X, et al. Oncogene, 2010 Sep 9. PMID 20581865.Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Wiedemeyer WR, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534551.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Michaud K, et al. Cancer Res, 2010 Apr 15. PMID 20354191.

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$ 315.00
Cat# AT1476a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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