CDKN1B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CDKN1B.
|Application ||WB, IHC, IF, E|
|Calculated MW||22073 Da|
|Other Names||Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1|
|Target/Specificity||CDKN1B (AAH01971, 1 a.a. ~ 198 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CDKN1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
JAB1 expression is associated with inverse expression of p27(kip1) in hepatocellular carcinoma. Qin J, et al. Hepatogastroenterology, 2010 May-Jun. PMID 20698225.CCND1 and CDKN1B polymorphisms and risk of breast cancer. Canbay E, et al. Anticancer Res, 2010 Jul. PMID 20683061.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Analysis of cyclin-dependent kinase inhibitor 1B mutation in Han Chinese women with premature ovarian failure. Wang B, et al. Reprod Biomed Online, 2010 Aug. PMID 20615757.The MENX syndrome and p27: relationships with multiple endocrine neoplasia. Molatore S, et al. Prog Brain Res, 2010. PMID 20541671.
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