CEBPE Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CEBPE.
|Calculated MW||30603 Da|
|Other Names||CCAAT/enhancer-binding protein epsilon, C/EBP epsilon, CEBPE|
|Target/Specificity||CEBPE (AAH35797.2, 1 a.a. ~ 281 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CEBPE Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. Prasad RB, et al. Blood, 2010 Mar 4. PMID 20042726.Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Papaemmanuil E, et al. Nat Genet, 2009 Sep. PMID 19684604.Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors. Cloutier A, et al. J Immunol, 2009 Jan 1. PMID 19109189.Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. Bedi R, et al. Blood, 2009 Jan 8. PMID 18832658.C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Matsushita H, et al. Oncogene, 2008 Dec 4. PMID 18776924.
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