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>   home   >   Products   >   Primary Antibodies   >   CENPA Antibody (monoclonal) (M01)   

CENPA Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant CENPA.

  • E - CENPA Antibody (monoclonal) (M01) AT1493a
    Detection limit for recombinant GST tagged CENPA is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49450
Other Accession BC000881
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1D4-1A3
Calculated MW 15991 Da
Additional Information
Gene ID 1058
Other Names Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA
Target/Specificity CENPA (AAH00881, 1 a.a. ~ 114 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCENPA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.


Dual recognition of CENP-A nucleosomes is required for centromere assembly. Carroll CW, et al. J Cell Biol, 2010 Jun 28. PMID 20566683.Molecular and evolutionary characteristics of the fraction of human alpha satellite DNA associated with CENP-A at the centromeres of chromosomes 1, 5, 19, and 21. Pironon N, et al. BMC Genomics, 2010 Mar 23. PMID 20331851.Building centromeres: home sweet home or a nomadic existence? Buscaino A, et al. Curr Opin Genet Dev, 2010 Apr. PMID 20206496.CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses. Maehara K, et al. Mol Cell Biol, 2010 May. PMID 20160010.HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Shuaib M, et al. Proc Natl Acad Sci U S A, 2010 Jan 26. PMID 20080577.

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$ 315.00
Cat# AT1493a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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