CENPJ Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CENPJ.
|Application ||WB, IHC, E|
|Calculated MW||153000 Da|
|Other Names||Centromere protein J, CENP-J, Centrosomal P41-associated protein, LAG-3-associated protein, LYST-interacting protein 1, CENPJ, CPAP, LAP, LIP1|
|Target/Specificity||CENPJ (NP_060921, 979 a.a. ~ 1088 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CENPJ Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation.
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. Chang J, et al. EMBO J, 2010 Jul 21. PMID 20531387.Novel CENPJ mutation causes Seckel syndrome. Al-Dosari MS, et al. J Med Genet, 2010 Jun. PMID 20522431.Sex-dependent association of common variants of microcephaly genes with brain structure. Rimol LM, et al. Proc Natl Acad Sci U S A, 2010 Jan 5. PMID 20080800.Dimerization of CPAP orchestrates centrosome cohesion plasticity. Zhao L, et al. J Biol Chem, 2010 Jan 22. PMID 19889632.CPAP is a cell-cycle regulated protein that controls centriole length. Tang CJ, et al. Nat Cell Biol, 2009 Jul. PMID 19503075.
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