CHST3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CHST3.
|Application ||WB, E|
|Calculated MW||54706 Da|
|Other Names||Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, C6ST-1, Chondroitin 6-sulfotransferase, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0, GST-0, CHST3|
|Target/Specificity||CHST3 (NP_004264, 312 a.a. ~ 411 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CHST3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis.
Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. Saito A, et al. J Hum Genet, 2009 Jun. PMID 19343046.Omani-type spondyloepiphyseal dysplasia with cardiac involvement caused by a missense mutation in CHST3. Tuysuz B, et al. Clin Genet, 2009 Apr. PMID 19320654.Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1. Kitagawa H, et al. J Biol Chem, 2008 Oct 10. PMID 18697746.Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis. Hermanns P, et al. Am J Hum Genet, 2008 Jun. PMID 18513679.Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. Nordgard SH, et al. Genes Chromosomes Cancer, 2008 Aug. PMID 18398821.
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