CITED4 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant CITED4.
|Application ||WB, IHC, IF|
|Calculated MW||18569 Da|
|Other Names||Cbp/p300-interacting transactivator 4, MSG1-related protein 2, MRG-2, CITED4 (HGNC:18696), MRG2|
|Target/Specificity||CITED4 (NP_597724.1, 131 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CITED4 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
CITED4 belongs to a family of transcriptional coactivators that bind several proteins, including CREB-binding protein (MIM 600140) and p300 (MIM 602700).
Mutational analysis of the CITED4 gene in glioblastomas. Torres-Mart?n M, et al. Cancer Genet Cytogenet, 2008 Sep. PMID 18722883.Hypermethylation and transcriptional downregulation of the CITED4 gene at 1p34.2 in oligodendroglial tumours with allelic losses on 1p and 19q. Tews B, et al. Oncogene, 2007 Jul 26. PMID 17311001.Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin. Labalette C, et al. Mol Cell Biol, 2004 Dec. PMID 15572674.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. Fox SB, et al. Cancer Res, 2004 Sep 1. PMID 15342390.
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