CKB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CKB.
|Application ||WB, IF|
|Calculated MW||42644 Da|
|Other Names||Creatine kinase B-type, B-CK, Creatine kinase B chain, CKB, CKBB|
|Target/Specificity||CKB (AAH01190, 1 a.a. ~ 381 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CKB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized.
Reduced creatine kinase B activity in multiple sclerosis normal appearing white matter. Steen C, et al. PLoS One, 2010 May 25. PMID 20520825.Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease. Kim J, et al. Biochim Biophys Acta, 2010 Jul-Aug. PMID 20460152.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. Martins-de-Souza D, et al. BMC Psychiatry, 2009 Apr 30. PMID 19405953.Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
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