|Application ||WB, E|
|Calculated MW||52495 Da|
|Other Names||Clusterin, Aging-associated gene 4 protein, Apolipoprotein J, Apo-J, Complement cytolysis inhibitor, CLI, Complement-associated protein SP-40, Ku70-binding protein 1, NA1/NA2, Testosterone-repressed prostate message 2, TRPM-2, Clusterin beta chain, ApoJalpha, Complement cytolysis inhibitor a chain, Clusterin alpha chain, ApoJbeta, Complement cytolysis inhibitor b chain, CLU, APOJ, CLI, KUB1|
|Target/Specificity||CLU (NP_001822, 402 a.a. ~ 501 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CLU Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene appears to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. However, the function of this protein is unknown. Three transcript variants encoding different isoforms have been found for this gene, and one of them is secreted and processed into a mature form.
Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old. Mengel-From J, et al. Neurobiol Aging, 2010 Aug 23. PMID 20739100.Association Analysis Between the rs11136000 Single Nucleotide Polymorphism in Clusterin Gene, rs3851179 Single Nucleotide Polymorphism in Clathrin Assembly Lymphoid Myeloid Protein Gene and the Patients with Schizophrenia in the Chinese Population. Zhou Y, et al. DNA Cell Biol, 2010 Aug 25. PMID 20738160.Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes. Jun G, et al. Arch Neurol, 2010 Sep 3. PMID 20697030.Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Yu JT, et al. Clin Chim Acta, 2010 Oct 9. PMID 20599866.Association of CLU and PICALM variants with Alzheimer's disease. Kamboh MI, et al. Neurobiol Aging, 2010 Jun 4. PMID 20570404.
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