CNOT2 Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant CNOT2.
|Calculated MW||59738 Da|
|Other Names||CCR4-NOT transcription complex subunit 2, CCR4-associated factor 2, CNOT2, CDC36, NOT2|
|Target/Specificity||CNOT2 (NP_055330, 441 a.a. ~ 540 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CNOT2 Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex. Miyasaka T, et al. Cancer Sci, 2008 Apr. PMID 18377426.Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Morita M, et al. Mol Cell Biol, 2007 Jul. PMID 17452450.Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. Winkler GS, et al. EMBO J, 2006 Jul 12. PMID 16778766.Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Jayne S, et al. Biochem J, 2006 Sep 15. PMID 16712523.
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