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CRSP7 Antibody (monoclonal) (M06)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1633a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
CRSP7 Antibody (monoclonal) (M06) - Product info | |
| Application | WB
|
| Primary Accession | O95402 |
| Other Accession | NP_004822 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 2G10 |
| Calculated MW | 65446 Da |
CRSP7 Antibody (monoclonal) (M06) - Additional info | |
| Gene ID 9441 | |
| Other Names CRSP70, MED26cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa | |
| Target/Specificity CRSP7 (NP_004822, 501 a.a. ~ 601 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CRSP7 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CRSP7 Antibody (monoclonal) (M06) - Related products
CRSP7 Antibody (monoclonal) (M06) - Application data
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Western Blot analysis of CRSP7 expression in transfected 293T cell line by CRSP7 monoclonal antibody (M06), clone 2G10.
Lane 1: CRSP7 transfected lysate(65.446 KDa).
Lane 2: Non-transfected lysate.
CRSP7 Antibody (monoclonal) (M06) - Research Areas
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BACKGROUND
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
REFERENCES
MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. Ding N, et al. J Biol Chem, 2009 Jan 30. PMID 19049968.Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Zhang X, et al. Mol Cell, 2005 Jul 1. PMID 15989967.A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Sato S, et al. Mol Cell, 2004 Jun 4. PMID 15175163.Ras induces mediator complex exchange on C/EBP beta. Mo X, et al. Mol Cell, 2004 Jan 30. PMID 14759369.
