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CRYGD Antibody (monoclonal) (M03)

Mouse monoclonal antibody raised against a partial recombinant CRYGD.

  • WB - CRYGD Antibody (monoclonal) (M03) AT1644a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - CRYGD Antibody (monoclonal) (M03) AT1644a
    CRYGD monoclonal antibody (M03), clone 4E12 Western Blot analysis of CRYGD expression in HepG2 ( (Cat # AT1644a )
  • E - CRYGD Antibody (monoclonal) (M03) AT1644a
    Detection limit for recombinant GST tagged CRYGD is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07320
Other Accession NM_006891
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 4.0E+12
Calculated MW 20738 Da
Additional Information
Gene ID 1421
Other Names Gamma-crystallin D, Gamma-D-crystallin, Gamma-crystallin 4, CRYGD, CRYG4
Target/Specificity CRYGD (NP_008822, 75 a.a. ~ 174 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCRYGD Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.


Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone. Acosta-Sampson L, et al. J Mol Biol, 2010 Aug 6. PMID 20621668.Increase in surface hydrophobicity of the cataract-associated P23T mutant of human gammaD-crystallin is responsible for its dramatically lower, retrograde solubility. Pande A, et al. Biochemistry, 2010 Jul 27. PMID 20553008.A novel human CRYGD mutation in a juvenile autosomal dominant cataract. Roshan M, et al. Mol Vis, 2010 May 22. PMID 20508808.beta-Strand interactions at the domain interface critical for the stability of human lens gammaD-crystallin. Das P, et al. Protein Sci, 2010 Jan. PMID 19937657.Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin. Moreau KL, et al. J Biol Chem, 2009 Nov 27. PMID 19758984.

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$ 315.00
Cat# AT1644a
(40 western blots)
Availability: 7-10 days
Bulk Size
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