CRYM Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant CRYM.
|Application ||WB, E|
|Calculated MW||33776 Da|
|Other Names||Ketimine reductase mu-crystallin, NADP-regulated thyroid-hormone-binding protein, CRYM, THBP|
|Target/Specificity||CRYM (NP_001879, 215 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CRYM Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2010 May 14. PMID 20471030.Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells. Al-Kafaji G, et al. Biochem Biophys Res Commun, 2010 Jan 22. PMID 20018174.Identification of mu-crystallin as an androgen-regulated gene in human prostate cancer. Malinowska K, et al. Prostate, 2009 Jul 1. PMID 19353593.Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. Martins-de-Souza D, et al. J Psychiatr Res, 2009 Jul. PMID 19110265.
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