CYGB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CYGB.
|Calculated MW||21405 Da|
|Other Names||Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP|
|Target/Specificity||CYGB (AAH29798, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||CYGB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002 [PubMed 11893755]).
Cytoglobin conformations and disulfide bond formation. Lechauve C, et al. FEBS J, 2010 Jun. PMID 20553503.Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. Gardner AM, et al. J Biol Chem, 2010 Jul 30. PMID 20511233.Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Shaw RJ, et al. Br J Cancer, 2009 Jul 7. PMID 19568272.Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. Halligan KE, et al. J Biol Chem, 2009 Mar 27. PMID 19147491.Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina. Ostoji? J, et al. Arch Ophthalmol, 2008 Nov. PMID 19001220.
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