DCTD Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant DCTD.
|Application ||WB, IHC, E|
|Calculated MW||20016 Da|
|Other Names||Deoxycytidylate deaminase, dCMP deaminase, DCTD|
|Target/Specificity||DCTD (NP_001912.2, 69 a.a. ~ 178 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DCTD Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Tanaka M, et al. Cancer, 2010 Jul 21. PMID 20665488.Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Okazaki T, et al. Clin Cancer Res, 2010 Jan 1. PMID 20028759.An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. Rha SY, et al. Oncologist, 2007 Jun. PMID 17602053.Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Rush J, et al. Nat Biotechnol, 2005 Jan. PMID 15592455.
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