DDX6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant DDX6.
|Application ||WB, IHC|
|Calculated MW||54417 Da|
|Other Names||Probable ATP-dependent RNA helicase DDX6, ATP-dependent RNA helicase p54, DEAD box protein 6, Oncogene RCK, DDX6, HLR2, RCK|
|Target/Specificity||DDX6 (AAH65007, 1 a.a. ~ 483 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||DDX6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.
1.DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells.Kawahara C, Yokota S, Fujita HHistochem Cell Biol. 2013 Oct 20.2.The DEAD-box RNA Helicase DDX6 is Required for Efficient Encapsidation of a Retroviral Genome.Yu SF, Lujan P, Jackson DL, Emerman M, Linial ML.PLoS Pathog. 2011 Oct;7(10):e1002303. Epub 2011 Oct 13.3.Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines.Broytman O, Westmark PR, Gurel Z, Malter JS.Neurobiol Aging. 2008 Mar 28 [Epub ahead of print]
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