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DEFB4 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1751a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
DEFB4 Antibody (monoclonal) (M01) - Product info | |
| Application | WB
|
| Primary Accession | O15263 |
| Other Accession | NP_004933 |
| Reactivity | Human |
| Concentration | 1 mg/ml |
| Isotype | IgG1 Kappa |
| Clone Names | 4C4 |
| Calculated MW | 7038 Da |
DEFB4 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 1673 | |
| Other Names DEFB2, DEFB102, DEFB2, HBD2, SAP1defensin, beta 4 | |
| Target/Specificity DEFB4 (NP_004933, 24 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions DEFB4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
DEFB4 Antibody (monoclonal) (M01) - Application data
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Western Blot analysis of DEFB4 expression in transfected 293T cell line by DEFB4 monoclonal antibody (M01), clone 4C4.
Lane 1: DEFB4 transfected lysate(7.038 KDa).
Lane 2: Non-transfected lysate. -
Detection limit for recombinant GST tagged DEFB4 is approximately 3ng/ml as a capture antibody.
DEFB4 Antibody (monoclonal) (M01) - Related products
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BACKGROUND
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation.
REFERENCES
Polymorphisms of Beta Defensins Are Associated with the Risk of Severe Acute Pancreatitis. Tiszlavicz Z, et al. Pancreatology, 2010 Aug 19. PMID 20720450.Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria. Yin L, et al. BMC Immunol, 2010 Jul 9. PMID 20618959.Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. R?hrl J, et al. J Immunol, 2010 Jun 15. PMID 20483750.Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease. Janssens W, et al. Am J Respir Crit Care Med, 2010 Jul 15. PMID 20378733.Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway. Yoon YM, et al. Infect Immun, 2010 May. PMID 20231411.
