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DMTF1 Antibody (monoclonal) (M03)

Mouse monoclonal antibody raised against a partial recombinant DMTF1.

  • WB - DMTF1 Antibody (monoclonal) (M03) AT1784a
    DMTF1 monoclonal antibody (M03), clone 5C6 Western Blot analysis of DMTF1 expression in Hela S3 NE ( Cat # L013V3 ).
  • IHC - DMTF1 Antibody (monoclonal) (M03) AT1784a
    Immunoperoxidase of monoclonal antibody to DMTF1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml]
  • IF - DMTF1 Antibody (monoclonal) (M03) AT1784a
    Immunofluorescence of monoclonal antibody to DMTF1 on HeLa cell. [antibody concentration 30 ug/ml]
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y222
Other Accession NM_021145
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 5C6
Calculated MW 84471 Da
Additional Information
Gene ID 9988
Other Names Cyclin-D-binding Myb-like transcription factor 1, hDMTF1, Cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1
Target/Specificity DMTF1 (NP_066968, 661 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsDMTF1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.


Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Liu Y, et al. Mol Psychiatry, 2010 Mar 30. PMID 20351715.Role of DMP1 and its future in lung cancer diagnostics. Sugiyama T, et al. Expert Rev Mol Diagn, 2008 Jul. PMID 18598225.Emerging roles of DMP1 in lung cancer. Inoue K, et al. Cancer Res, 2008 Jun 15. PMID 18559489.The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Tschan MP, et al. Leukemia, 2008 May. PMID 17972942.Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Mallakin A, et al. Cancer Cell, 2007 Oct. PMID 17936562.

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$ 315.00
Cat# AT1784a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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