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DUT Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant DUT.

  • WB - DUT Antibody (monoclonal) (M01) AT1831a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.3 KDa) .
  • WB - DUT Antibody (monoclonal) (M01) AT1831a
    Western Blot analysis of DUT expression in transfected 293T cell line by DUT monoclonal antibody (M01), clone 1C9.

    Lane 1: DUT transfected lysate(18 KDa).
    Lane 2: Non-transfected lysate.
  • IHC - DUT Antibody (monoclonal) (M01) AT1831a
    Immunoperoxidase of monoclonal antibody to DUT on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml]
  • IF - DUT Antibody (monoclonal) (M01) AT1831a
    Immunofluorescence of monoclonal antibody to DUT on HeLa cell . [antibody concentration 10 ug/ml]
  • E - DUT Antibody (monoclonal) (M01) AT1831a
    Detection limit for recombinant GST tagged DUT is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P33316
Other Accession BC033645
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 1C9
Calculated MW 26563 Da
Additional Information
Gene ID 1854
Other Names Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, dUTP pyrophosphatase, DUT
Target/Specificity DUT (AAH33645, 68 a.a. ~ 164 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsDUT Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.


dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma. Takatori H, et al. Liver Int, 2010 Mar. PMID 19968781.Kinetic properties and specificity of trimeric Plasmodium falciparum and human dUTPases. Quesada-Soriano I, et al. Biochimie, 2010 Feb. PMID 19879316.Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. Chanson A, et al. Am J Clin Nutr, 2009 Jun. PMID 19403629.Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers. Tak?cs E, et al. FEBS Lett, 2009 Mar 4. PMID 19302784.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.

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$ 315.00
Cat# AT1831a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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