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DVL3 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant DVL3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q92997 |
| Other Accession | BC032459 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4H2 |
| Calculated MW | 78055 Da |
| Gene ID | 1857 |
|---|---|
| Other Names | Segment polarity protein dishevelled homolog DVL-3, Dishevelled-3, DSH homolog 3, DVL3, KIAA0208 |
| Target/Specificity | DVL3 (AAH32459, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | DVL3 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
References
Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Gnad T, et al. Mol Cancer, 2010 Feb 5. PMID 20137080.Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein. Bouteille N, et al. Oncogene, 2009 Jul 16. PMID 19465938.Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma. Fukukawa C, et al. Oncogene, 2009 Feb 26. PMID 19137009.Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Wei Q, et al. Lung Cancer, 2008 Nov. PMID 18692936.Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Lee YN, et al. Cell Signal, 2008 Feb. PMID 18093802.
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