EBAG9 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a full-length recombinant EBAG9.
|Application ||WB, E|
|Calculated MW||24377 Da|
|Other Names||Receptor-binding cancer antigen expressed on SiSo cells, Cancer-associated surface antigen RCAS1, Estrogen receptor-binding fragment-associated gene 9 protein, EBAG9, RCAS1|
|Target/Specificity||EBAG9 (AAH17729, 1 a.a. ~ 213 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||EBAG9 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.
Analysis of the expression of human tumor antigens in ovarian cancer tissues. Ali-Fehmi R, et al. Cancer Biomark, 2010. PMID 20164540.Receptor-binding cancer antigen expressed on SiSo cells induces apoptosis via ectodomain shedding. Sonoda K, et al. Exp Cell Res, 2010 Jul 1. PMID 20079734.[Evaluation of RCAS1 as serum tumor marker for pancreatic cancer] Yang YC, et al. Zhonghua Wai Ke Za Zhi, 2009 Jul 1. PMID 19957811.Expression of RCAS1 protein in microglia/macrophages accompanying brain tumours. An immunofluorescence study. Adamek D, et al. Folia Neuropathol, 2009. PMID 19813143.Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients. Giaginis C, et al. Int J Biol Markers, 2009 Apr-Jun. PMID 19634109.
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