EGR1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant EGR1.
|Application ||WB, E|
|Calculated MW||57507 Da|
|Other Names||Early growth response protein 1, EGR-1, AT225, Nerve growth factor-induced protein A, NGFI-A, Transcription factor ETR103, Transcription factor Zif268, Zinc finger protein 225, Zinc finger protein Krox-24, EGR1, KROX24, ZNF225|
|Target/Specificity||EGR1 (NP_001955, 444 a.a. ~ 543 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||EGR1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
Cigarette smoke-induced Egr-1 represses T beta R-II expression in human skin dermal fibroblasts. Kim JN, et al. Toxicology, 2010 Sep 10. PMID 20621662.Advanced glycation end product (AGE)-receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages. Xu Y, et al. J Biol Chem, 2010 Jul 23. PMID 20507991.Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells. Patel N, et al. J Biol Chem, 2010 Jul 2. PMID 20448047.Mature human neutrophils constitutively express the transcription factor EGR-1. Cullen EM, et al. Mol Immunol, 2010 May. PMID 20363028.The effect of siRNA-Egr-1 and camptothecin on growth and chemosensitivity of breast cancer cell lines. Parra E, et al. Oncol Rep, 2010 Apr. PMID 20204305.
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