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EIF4ENIF1 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT1879a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
EIF4ENIF1 Antibody (monoclonal) (M01) - Product info | |
| Application | WB
|
| Primary Accession | Q9NRA8 |
| Other Accession | NP_062817 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 2C4 |
| Calculated MW | 108201 Da |
EIF4ENIF1 Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 56478 | |
| Other Names 4E-T, Clast4, FLJ21601eukaryotic translation initiation factor 4E nuclear import factor 1 | |
| Target/Specificity EIF4ENIF1 (NP_062817, 886 a.a. ~ 986 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions EIF4ENIF1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
EIF4ENIF1 Antibody (monoclonal) (M01) - Related products
EIF4ENIF1 Antibody (monoclonal) (M01) - Application data
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Western Blot analysis of EIF4ENIF1 expression in transfected 293T cell line by EIF4ENIF1 monoclonal antibody (M01), clone 2C4.
Lane 1: EIF4ENIF1 transfected lysate(108.201 KDa).
Lane 2: Non-transfected lysate.
EIF4ENIF1 Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. Suzuki Y, et al. J Biol Chem, 2009 Dec 18. PMID 19850929.An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation. Lee HC, et al. Biochem Biophys Res Commun, 2008 May 16. PMID 18343217.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F, et al. Genome Res, 2007 Jun. PMID 17567994.
