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ELA2 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant ELA2.

  • E - ELA2 Antibody (monoclonal) (M05) AT1887a
    Detection limit for recombinant GST tagged ELA2 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08246
Other Accession NM_001972
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 3E6
Calculated MW 28518 Da
Additional Information
Gene ID 1991
Other Names Neutrophil elastase, Bone marrow serine protease, Elastase-2, Human leukocyte elastase, HLE, Medullasin, PMN elastase, ELANE, ELA2
Target/Specificity ELA2 (NP_001963, 168 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsELA2 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.


Cyclic neutropenia and severe congenital neutropenia in patients with a shared ELANE mutation and paternal haplotype: evidence for phenotype determination by modifying genes. Newburger PE, et al. Pediatr Blood Cancer, 2010 Aug. PMID 20582973.Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions. Hayashi M, et al. J Nippon Med Sch, 2010 Apr. PMID 20453419.Structures of human proteinase 3 and neutrophil elastase--so similar yet so different. Hajjar E, et al. FEBS J, 2010 May. PMID 20423453.Efficacy of neutrophil elastase inhibitor on type A acute aortic dissection. Niino T, et al. Thorac Cardiovasc Surg, 2010 Apr. PMID 20376727.Effect of a neutrophil elastase inhibitor on acute lung injury after cardiopulmonary bypass. Fujii M, et al. Interact Cardiovasc Thorac Surg, 2010 Jun. PMID 20354035.

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$ 315.00
Cat# AT1887a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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