ENG Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ENG.
|Application ||WB, IP, E|
|Calculated MW||70578 Da|
|Other Names||Endoglin, CD105, ENG, END|
|Target/Specificity||ENG (AAH14271, 27 a.a. ~ 658 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ENG Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Soluble endoglin in preeclamptic patients with or without HELLP syndrome. Hertig A, et al. Am J Obstet Gynecol, 2010 Jun. PMID 20430360.Update on molecular diagnosis of hereditary hemorrhagic telangiectasia. Richards-Yutz J, et al. Hum Genet, 2010 Jul. PMID 20414677.Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. Roberts KE, et al. Gastroenterology, 2010 Jul. PMID 20346360.Alterations of serum and placental endoglin in pre-eclampsia. Fang M, et al. J Int Med Res, 2010 Jan-Feb. PMID 20233512.
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