EPB41 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant EPB41.
|Application ||WB, IHC, IF, E|
|Calculated MW||97017 Da|
|Other Names||Protein 41, P41, 41R, Band 41, EPB41, EPB41, E41P|
|Target/Specificity||EPB41 (AAH39079, 116 a.a. ~ 225 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||EPB41 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population. Xue F, et al. Arch Oral Biol, 2010 Aug 24. PMID 20797695.Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. Korsgren C, et al. J Biol Chem, 2010 Feb 12. PMID 20007969.Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene. Huang SC, et al. Blood, 2009 Nov 5. PMID 19729518.Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain. Kusunoki H, et al. Proteins, 2009 Jul. PMID 19338061.Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells. Seo PS, et al. Biochim Biophys Acta, 2009 Feb. PMID 18952129.
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